Industasis, a promotion of tumor formation by nontumorigenic stray cells.

The Effect of Wild Type P53 Gene Transfer on Growth Properties and Tumorigenicity of PANC-1 Tumor Cell Line

The p53 protein function is essential for the maintenance of the nontumorigenic cell phenotype. Pancreatic tumor cells show a very high frequency of p53 mutation. To determine if restoration of wild type p53 function can be used to eliminate the tumorigenic phenotype in these cells, pancreatic tumor cell lines, PANC-1 and HTB80, differing in p53 status were stably transfected with exogenous wil...

Effect of Hyperthermia on self-renewality of prostate cancer stem cells

Introduction: Prostate cancer (PCa) is the most prevalent malignant tumor in the male population worldwide and it is the second leading cause of cancer-related death in males. PCa is almost incurable due to the resistance of PCa to conventional treatments. Cancer stem cells (CSCs) theory suggests that a small subpopulation of cancer cells is responsible for tumor development, ...

ON THE FORMATION OF STRAY GRAINS IN DIRECTIONALLY-SOLIDIFIED NI-BASED SUPERALLOYS WITH VARYING CROSS SECTIONS

Formation of stray grain defects particularly around re-entrant features of the turbine blade airfoils is one of the major problems in directional and single crystal solidification processes. In this work, directional solidification tests of the GTD-111 Ni-based superalloy were conducted at different withdrawal velocities of 3, 6 and 9 mm.min-1 using various stepped cylindrical and cubic design...

Melanoma Cells Tumor Formation in Nontumorigenic Protein-1 Stimulation of Monocytes Leads to Low-Level Monocyte Chemoattractant

Cytokine-induced nitric oxide formation in normal but not in neoplastic murine lung epithelial cell lines.

Cytomix, a mixture of interferon-γ, tumor necrosis factor-α, and interleukin-1β, induces nitric oxide (NO) production in lung epithelial cell lines. It is not known whether neoplastic transformation alters a cell's ability to form NO in response to cytokines. The present study investigated NO formation in two murine lines of immortalized "normal" (nontumorigenic) lung epithelial cells of alveol...